Disturbed temporal dynamics of episodic retrieval activity with preserved spatial activity pattern in amnestic mild cognitive impairment: A simultaneous EEG-fMRI study

• The HC and aMCI subjects showed similar retrieval success patterns in fMRI analysis. diminished ERP old/new effects within the pattern. Disturbed correlate of recollection component was related to EM function. disturbed cognitive processes despite preserved Episodic memory (EM) deficit is core dysfunction amnestic mild impairment (aMCI). However, episodic pattern detected by functional MRI (fMRI) appears subjects. To address this discrepancy, simultaneous electroencephalography (EEG)-fMRI recording employed determine whether temporal dynamics brain activity were patients with aMCI. Twenty-six 29 healthy control (HC) completed a word-list task during EEG-fMRI. activation analysis, familiarity- recollection-related components identified using event-related potential (ERP) fMRI-constrained analysis explored pattern, ERP-informed correlates familiarity processes. two groups exhibited bilateral posteromedial parietal cortex, left inferior lobule (IPL), lateral prefrontal cortex (LPFC). that group did not exhibit IPL LPFC observed group. In addition, associated performance. Therefore, study, we spatial Taken together, EEG-fMRI technique demonstrated identify individuals high risk deterioration.